Which of the following substances lack effective treatment medications?

Cocaine and marijuana are substances for which there are no widely accepted, effective pharmacological treatments specifically approved for use in treating addiction or dependence.

In the case of cocaine, while research is ongoing, there are currently no FDA-approved medications that effectively manage dependence or cravings directly linked to its use. Treatment for cocaine addiction is often centered on behavioral therapies and counseling rather than medication. This reflects the complexities of addiction where effective pharmacological interventions have not yet been developed.

Regarding marijuana, it is considered a less harmful substance compared to other illicit drugs, and while there are medications derived from its compounds used to manage certain conditions (like nausea in chemotherapy), there are no approved medications specifically aimed at treating cannabis use disorder. Typically, the approach for individuals struggling with marijuana addiction involves counseling and psychosocial interventions rather than pharmacotherapy.

Thus, both cocaine and marijuana are substances for which effective treatment medications are lacking, confirming that the correct choice is that both of the listed substances do not have specific medications for treatment.