As tolerance for barbiturates develops, the effects of the drug become less intense at the same dosage, meaning that users may need to consume larger amounts to achieve the same level of intoxication they initially experienced. This process can lead to a significant alteration in the body's response to the drug.
In the context of barbiturates, it is important to recognize that while individuals may feel less of the intoxicating effects over time, the potential for lethal overdose does not substantially change. The relationship between intoxication and lethality remains relatively constant, as the increased amounts of barbiturates required to achieve similar effects can also elevate the risk of overdose.
This characteristic of barbiturates highlights the dangers associated with their use; individuals may mistakenly believe they can safely increase their dosage without understanding that the risk for overdose remains present. Thus, the overall margin between intoxication and lethality stays the same even as tolerance develops.